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CoQ 10
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CoQ10

Integrated Medicine

Treatments

Coenzyme Q, found in all plant and animal cells as part of the mitochondria (components of cells that produce energy for the cell and are rich in fats, proteins, and enzymes), is necessary for energy production. Coenzyme Q10, also known as uniquinone, is one form of coenzyme Q and is used for energy production in humans. It is principally found in the liver, while some is made from food. The primary sources are meat, fish and vegetable oils.

How This Supplement Works in Your Body:

  • Produces Energy in the form of ATP (adenosine triphosphate)
  • Protects against free radical damage to cell structures and other substances in the body.
  • Controls flow of oxygen within individual cells
  • Increases circulation
  • Boosts the immune system
  • improve heart-muscle metabolism
  • Potential treatment for chest pain caused by narrowed coronary arteries (coronary insufficiency)
  • lower blood pressure
  • treat congestive heart failure by enhancing pumping action of heart
  • be effective in congestive heart failure, ischemic heart disease

Where This Supplement is Found:

  • Soybean oil
  • Sesame oil
  • Canola oil
  • Wheat germ
  • Rice bran
  • Soybeans
  • Spinach
  • Broccoli
  • Beef
  • Salmon
  • Mackerel
  • Peanuts
  • Spinach
  • Sardines

How to Use:
Available as:
Tablets and capsules. Oil-based supplements be absorbed more efficiently. Coenzyme Q10 maybe take up to 4-8 weeks to build up to peak levels in the body and thus result in noticeable effects.

Cautions:
Don’t take if you have:
Heart disease, without first consulting with a medical professional

Consult your doctor if you:
Take any medicinal drugs or herbs including aspirin, laxatives, cold and cough remedies, antacids, vitamins, minerals, amino acids, supplements, other prescription or nonprescription drugs.

Pregnancy:
More dangers are associated with its use than benefits.
Do not use.

Breastfeeding:
More dangers are associated with its use than benefits.
Do not use.

Infants and Children:
It is hazardous to treat infants and children under 2 with any supplement.

If not pregnant and do not consume amounts larger than a highly regarded manufacturer recommends on the package, no problems are expected.

Safe dosage:
To date, there has been no “safe” dosage established.

Toxicity:
There have been no toxic effects reported, even when administered at high doses.

Deficiency:
be caused by nutritional deficiencies, a genetic or acquired defect in synthesis or because of increased tissue needs due to a medical condition. Affects the heart due to the large amount of ATP needed in order to function. Has been linked to cancer, muscular dystrophy, diabetes, obesity, periodontal disease, lowered immune function and neurodegenerative disorders such as Parkinson’s disease.

Interactions:
Interacts with :

  • Vitamins B6, Vitamin C, Vitamin B12, folic acid, riboflavin, niacin, pantothenic acid : All required for the synthesis of Coenzyme Q10
  • Vitamin E : Protects Vitamin E from damage
  • Coenzyme Q10 : Lessens the toxic effects of doxorubicin
  • Beta blockers : Impede on the production and function of Coenzyme Q10, and greatly affect heart function
  • Lovastatin, pravastatin, and simvastatin : Inhibit HMG-CoA reductase, thus lowering levels of Coenzyme Q10
  • Phenothiazine, Neuroleptics, tricyclic antidepressants : Have effects of the function of the heart
Acidophilus (Lactobacillus)
Blue-Green Algae (Spirulina, Spirulina Maxima) Spirulina Platensis
Calcium (Calcium citrate) Calcium Gluconate)
Choline
Chondroitin Sulfate
Coenzyme Q (CoQ, Ubiquinoe, Coenzyme Q10)
Conjugated Linoleic Acid (CLA)
Creatine
Dehydroepiandrosterone (DHEA)
Desiccated Liver (Dessicated Liver)
Gamma-Linolenic Acid (GLA) Evening Primrose Oil)
Ginkgo Biloba (Ginkgoaceae)
 
Ginseng (Asian, American, Korean, Chinese, Panax, Quinquefolius)
Inositol (Myoinositol)
Iron (Ferrous Sulfate)

Jojoba (Goatnut, Simmondsia Chinensis)
L-Carnitine
Lecithin (Phosphatidylcholine)
Magnesium
Melatonin
Omega 3 Fatty Acids
Para-Aminobenzoic Acid (PABA)
Potassium (Potassium Chloride, Trikates)
Pregnenolone
Royal Jelly
 
Vitamin B-1 (Thiamine)
Vitamin B-2 (Riboflavin)
Vitamin B-3 (Niacin)
Vitamin B-5 (Pantothenic Acid)

Vitamin B-6 (Pyridoxine, pyridoxal phosphate)
Vitamin B-9 (Folic Acid) Folate, Pteroyiglutamic Acid) Folacin)
Vitamin B-12 (Cyanocobalamin)
Vitamin C (Ascorbic Acid)
Vitamin D (cholecalciferol, sunshine vitamin)
Vitamin E (alpha-tocopherol)
Vitamin H (Biotin)
Vitamin K (Phytonadione)
Vitamin P (Bioflavonoids, Phytochemicals)

 

CoQ10 Effective for Some Respiratory Problems

This report from France illustrates the importance and value of coenzyme Q10 (ubiquinone), especially concerning respiratory function.

  • The authors note that the respiratory-chain deficiencies are a broad group of largely untreatable diseases.
  • There is a subclass of patients with these disorders who suffer from a coenzyme Q10 deficiency.
  • Deficiency of coenzyme Q10-dependent respiratory-chain activities was identified in muscle biopsy, circulating lymphocytes, and cultured skin fibroblasts of 2 siblings with this disorder.
  • Undetectable coenzyme Q10 in cultured fibroblasts supported the diagnosis of widespread coenzyme Q10 deficiency.
  • The patients were treated with oral CoQ10 (5 mg/kg daily), which resulted in a substantial improvement of their condition over 3 years of therapy.

The authors conclude that particular attention should be paid to the fact that some patients with respiratory-chain enzyme deficiency may be successfully treated by oral CoQ10.

Lancet August 18, 2000; 356: 391-95

FDA Grants Orphan Drug Status to CoQ10

In an unusual move that boosts the credibility of the nutritional supplement industry, the U.S. Food and Drug Administration (FDA) has granted Orphan Drug designation to Tishcon Corp.'s (Westbury, NY) UbiQGel (Coenzyme Q10) treatment for mitochondrial cytopathies (MC).

Under the Orphan Drug Act, the FDA is given the authority to expedite drug approval under unusual circumstances. The agency may also award research grants for conducting clinical studies. Upon successful completion of the clinical trials, the FDA awards developers seven years of marketing exclusivity. These incentives allow companies to invest in the development of drugs aimed at treating rare or "orphan" diseases.

Mitochondrial Cytopathies encompass a group of debilitating diseases, which are in most cases caused by an inherited mitochondrial defect or dysfunction. MELAS syndrome, Kearns-Sayre syndrome, and MERRF syndrome are some of the more common mitochondrial diseases.
According to Raj Chopra, president of Tishcon, clinical trials of UbiQGel in mitochondrial cytopathy patients will begin this fall, and should be completed in approximately two years.

UbiQGel contains coenzyme Q10, a nutritional supplement, as its active component. As an essential cofactor in mitochondrial energy production, coenzyme Q10 is synthesized in the body and is also obtained through food. UbiQGel allegedly is a more bioavailable form of Q10.

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This information is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient's medical condition.
In no event will The DrEddyClinic.com be liable for any decision made or action taken in reliance upon the information provided through this web site.

 


 



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Last Modified : 03/15/08 04:13 AM