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CoQ10
Coenzyme Q, found in all plant and animal cells as part of the
mitochondria (components of cells that produce energy for the cell and
are rich in fats, proteins, and enzymes), is necessary for energy
production. Coenzyme Q10, also known as uniquinone, is one form of
coenzyme Q and is used for energy production in humans. It is
principally found in the liver, while some is made from food. The
primary sources are meat, fish and vegetable oils.
How This Supplement Works in Your Body:
- Produces Energy in the form of ATP (adenosine triphosphate)
- Protects against free radical damage to cell structures and other
substances in the body.
- Controls flow of oxygen within individual cells
- Increases circulation
- Boosts the immune system
- improve heart-muscle metabolism
- Potential treatment for
chest pain caused by narrowed coronary arteries
(coronary insufficiency)
- lower blood pressure
- treat congestive
heart failure by enhancing pumping action of heart
- be effective in congestive heart failure, ischemic heart disease
Where This Supplement is Found:
- Soybean oil
- Sesame oil
- Canola oil
- Wheat germ
- Rice bran
- Soybeans
- Spinach
- Broccoli
- Beef
- Salmon
- Mackerel
- Peanuts
- Spinach
- Sardines
How to Use:
Available as:
Tablets and capsules. Oil-based supplements be absorbed more
efficiently. Coenzyme Q10 maybe take up to 4-8 weeks to build up to peak
levels in the body and thus result in noticeable effects.
Cautions:
Don’t take if you have:
Heart disease, without first consulting with a medical professional
Consult your doctor if you:
Take any medicinal drugs or herbs including aspirin, laxatives, cold and
cough remedies, antacids, vitamins, minerals, amino acids, supplements,
other prescription or nonprescription drugs.
Pregnancy:
More dangers are associated with its use than benefits.
Do not use.
Breastfeeding:
More dangers are associated with its use than benefits.
Do not use.
Infants and Children:
It is hazardous to treat infants and children under 2 with any
supplement.
If not
pregnant and do not consume amounts larger than a highly regarded
manufacturer recommends on the package, no problems are expected.
Safe dosage:
To date, there has been no “safe” dosage established.
Toxicity:
There have been no toxic effects reported, even when administered at
high doses.
Deficiency:
be caused by nutritional deficiencies, a genetic or acquired defect
in synthesis or because of increased tissue needs due to a medical
condition. Affects the heart due to the large amount of ATP needed in
order to function. Has been linked to cancer, muscular dystrophy,
diabetes, obesity, periodontal disease, lowered immune function and
neurodegenerative disorders such as Parkinson’s disease.
Interactions:
Interacts with :
- Vitamins B6,
Vitamin C, Vitamin B12,
folic acid,
riboflavin,
niacin,
pantothenic acid : All required for the synthesis of Coenzyme Q10
- Vitamin E : Protects
Vitamin E from damage
- Coenzyme Q10 : Lessens the toxic effects of doxorubicin
- Beta blockers : Impede on the production and function of Coenzyme Q10,
and greatly affect heart
function
- Lovastatin, pravastatin, and simvastatin : Inhibit HMG-CoA reductase,
thus lowering levels of Coenzyme
Q10
- Phenothiazine, Neuroleptics, tricyclic antidepressants : Have effects of
the function of the heart
Acidophilus (Lactobacillus)
Blue-Green Algae (Spirulina,
Spirulina Maxima) Spirulina Platensis
Calcium (Calcium citrate) Calcium Gluconate)
Choline
Chondroitin Sulfate
Coenzyme Q (CoQ, Ubiquinoe, Coenzyme
Q10)
Conjugated Linoleic Acid (CLA)
Creatine
Dehydroepiandrosterone (DHEA)
Desiccated Liver (Dessicated Liver)
Gamma-Linolenic Acid (GLA) Evening
Primrose Oil)
Ginkgo Biloba (Ginkgoaceae) |
Ginseng (Asian, American, Korean,
Chinese, Panax, Quinquefolius)
Inositol (Myoinositol)
Iron (Ferrous Sulfate)
Jojoba (Goatnut, Simmondsia Chinensis)
L-Carnitine
Lecithin (Phosphatidylcholine)
Magnesium
Melatonin
Omega 3 Fatty Acids
Para-Aminobenzoic Acid (PABA)
Potassium (Potassium Chloride,
Trikates)
Pregnenolone
Royal Jelly
|
Vitamin B-1 (Thiamine)
Vitamin B-2 (Riboflavin)
Vitamin B-3 (Niacin)
Vitamin B-5 (Pantothenic Acid)
Vitamin B-6 (Pyridoxine, pyridoxal
phosphate)
Vitamin B-9 (Folic Acid) Folate,
Pteroyiglutamic Acid) Folacin)
Vitamin B-12 (Cyanocobalamin)
Vitamin C (Ascorbic Acid)
Vitamin D (cholecalciferol, sunshine
vitamin)
Vitamin E (alpha-tocopherol)
Vitamin H (Biotin)
Vitamin K (Phytonadione)
Vitamin P (Bioflavonoids,
Phytochemicals) |
CoQ10 Effective
for Some Respiratory Problems
This report from
France illustrates the importance and value of coenzyme Q10 (ubiquinone),
especially concerning respiratory function.
- The authors note that the respiratory-chain
deficiencies are a broad group of largely untreatable diseases.
- There is a subclass of patients with these
disorders who suffer from a coenzyme Q10 deficiency.
- Deficiency of coenzyme Q10-dependent
respiratory-chain activities was identified in muscle biopsy,
circulating lymphocytes, and cultured skin fibroblasts of 2 siblings
with this disorder.
- Undetectable coenzyme Q10 in cultured fibroblasts
supported the diagnosis of widespread coenzyme Q10 deficiency.
- The patients were treated with oral CoQ10 (5 mg/kg
daily), which resulted in a substantial improvement of their
condition over 3 years of therapy.
The authors conclude
that particular attention should be paid to the fact that some patients
with respiratory-chain enzyme deficiency may be successfully treated by
oral CoQ10.
Lancet
August 18, 2000; 356: 391-95
FDA Grants Orphan Drug
Status to CoQ10
In an unusual move
that boosts the credibility of the nutritional supplement industry, the
U.S. Food and Drug Administration (FDA) has granted Orphan Drug
designation to Tishcon Corp.'s (Westbury, NY) UbiQGel (Coenzyme Q10)
treatment for mitochondrial cytopathies (MC).
Under the Orphan
Drug Act, the FDA is given the authority to expedite drug approval under
unusual circumstances. The agency may also award research grants for
conducting clinical studies. Upon successful completion of the clinical
trials, the FDA awards developers seven years of marketing exclusivity.
These incentives allow companies to invest in the development of drugs
aimed at treating rare or "orphan" diseases.
Mitochondrial
Cytopathies encompass a group of debilitating diseases, which are in
most cases caused by an inherited mitochondrial defect or dysfunction.
MELAS syndrome, Kearns-Sayre syndrome, and MERRF syndrome are some of
the more common mitochondrial diseases.
According to Raj Chopra, president of Tishcon, clinical trials of
UbiQGel in mitochondrial cytopathy patients will begin this fall, and
should be completed in approximately two years.
UbiQGel contains
coenzyme Q10, a nutritional supplement, as its active component. As an
essential cofactor in mitochondrial energy production, coenzyme Q10 is
synthesized in the body and is also obtained through food. UbiQGel
allegedly is a more bioavailable form of Q10.

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This information is
provided for general medical education purposes only and
is not meant to substitute for the independent medical
judgment of a physician relative to diagnostic and
treatment options of a specific patient's medical
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