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Nonulcer dyspepsia (indigestion)

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From MayoClinic.com

Screening and diagnosis

To make a diagnosis of nonulcer dyspepsia, your doctor first will likely rule out other medical problems that can cause abdominal pain and indigestion, such as:

  • An ulcer. An ulcer is an open sore that develops on the inside lining of your stomach, upper small intestine or esophagus.

  • Gastroesophageal reflux disease (GERD). This is a condition in which stomach acid backs up into your food pipe (esophagus) causing esophageal irritation or inflammation.

  • Gastritis. This is inflammation of the lining of your stomach, which you may experience as a gnawing or burning pain in your stomach or upper abdomen.

  • Gallstones. These solid deposits of cholesterol or calcium salts form in your gallbladder or nearby bile ducts and can cause symptoms such as nausea and an intense, steady ache in the upper-middle or upper-right abdomen.

  • Diseases of the liver. These may include fatty liver, cirrhosis, or liver cancer.

  • Diseases of the pancreas. These may include pancreatitis or pancreatic cancer.

  • Irritable bowel syndrome (IBS). IBS is characterized by abdominal pain or cramping and changes in bowel function, including bloating, gas, diarrhea and constipation.

  • Celiac disease. This condition is triggered by consumption of the protein gluten, which is found in foods that contain wheat, barley, rye or oats.

  • Crohn's disease. Crohn's disease is an inflammatory condition that can affect any part of your digestive tract, most often the lower part of the small intestine.

Your doctor will likely review your signs and symptoms and perform a physical examination. A number of diagnostic tests may help your doctor determine the cause of your discomfort. These may include:

  • Laboratory tests. Blood tests may help rule out other diseases that can cause signs and symptoms similar to those of nonulcer dyspepsia.

  • Barium X-ray or contrast study. For this test, you drink a barium solution. The barium, which shows up on X-rays, coats the inside of your upper digestive tract. Your doctor is then better able to examine your upper gastrointestinal tract and small bowel for the presence of ulcers, tumors, strictures, and other abnormalities.

  • Endoscopy. A thin, flexible, lighted instrument (endoscope) is passed down your throat so that your doctor can view your esophagus, stomach, and the first part of your small intestine (duodenum).

  • Ultrasound. Ultrasound imaging uses high-frequency sound waves to create images of your gastrointestinal organs, especially your gallbladder, liver and pancreas. Doctors commonly use this method to look for subtle differences between healthy and unhealthy areas in the organs of the abdomen.


Because nonulcer dyspepsia is a disorder unrelated to disease, it doesn't lead to more-serious conditions. However, complications may include:

  • Problems caused by tests done to rule out other disorders

  • Side effects of medications taken to treat the condition

  • Worry about having other conditions



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