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Peyronie's disease
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Peyronie's disease

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Because the course of Peyronie's disease differs from man to man and some men experience improvement without treatment, doctors often initially recommend a wait-and-see approach. Your doctor may suggest monitoring the progression of the disease for nine to 12 months by assessing plaque formation, penile curvature and erectile function before attempting treatment. Some treatments — surgical and nonsurgical — can increase a man's risk of ED.

Nonsurgical methods

If Peyronie's disease doesn't improve without treatment, your doctor may suggest one of the following nonsurgical treatments:

  • Vitamin E. Researchers have reported improvements in Peyronie's disease when vitamin E is taken orally, yet the effectiveness of vitamin E therapy has yet to be proved in controlled studies. Similar research exists on para-aminobenzoate, a substance belonging to the family of B complex molecules. The benefit of para-aminobenzoate also remains unproved.

  • Intralesional injections. Your doctor can inject drugs such as collagenase, verapamil or other calcium channel blockers directly into the plaque. These drugs are intended to break down scar tissue deposits and return the tissue building process to normal. Multiple injections occur over a period of up to three months. The success of intralesional injections varies. Intralesional injection of steroids, such as cortisone, has caused harmful side effects to healthy penile tissues.


If other methods of treatment don't help and your penis is still curved or bent when erect, surgery may be an option. Doctors usually suggest surgery when unacceptable appearance, pain during intercourse and poor erection quality persist for one to 2 years or longer. Surgery is generally effective at restoring normal erections, although each method can cause unwelcome side effects such as partial loss of erection or shortening of an erect penis.

Common surgical methods include:

  • Plaque excision. The plaque is removed and replaced with a patch of skin from the pubic area.

  • Nesbit plication. Tissue on the opposite side of the penis is removed or pinched, canceling the bending effect.

  • Plaque incision with saphenous vein graft. Several linear cuts are made in the plaque, which allows straightening. The cut plaque is then covered with a grafted vein.

  • Penile prosthesis. An implanted device is used to straighten and increase the rigidity of the penis.


There's no known prevention for Peyronie's disease. It's possible that the problem may begin with trauma to the penis from being hit or bent abnormally when erect or during sexual intercourse. Avoiding injury to your penis when erect may prevent the development of Peyronie's disease. However, trauma to the penis doesn't explain all cases of the disorder.

Coping skills

Peyronie's disease can become a source of mental and emotional stress for you and your partner. Having the disease shouldn't be seen as a reflection of your health, virility or masculinity. If you have Peyronie's disease that has progressed to include erectile dysfunction, remember that your partner may see your inability to have intercourse as a sign of diminished sexual desire. Your reassurance that this isn't the case can help your relationship.

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