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Paget's disease of bone
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Paget's disease of bone

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From MayoClinic.com

Screening and diagnosis

The first indication of Paget's disease is often either an elevated alkaline phosphatase level found in blood testing or abnormalities found on X-rays done for other reasons. X-ray images of your bones can show areas of bone reabsorption, enlargement of the bone, and deformities that are characteristic of Paget's disease, such as bowing of the long bones. A diagnosis of Paget's disease can be based on the X-ray findings in most people.

In some cases, your physician also may recommend a bone scan. Bone scans can pick up Paget's disease before it can be seen on an X-ray. Doctors also use bone scans to determine which bones are affected. In a bone scan, radioactive tracers are injected into your body. The tracers are taken up by your bones and give off radiation that is captured by a special camera, which produces a picture of your skeleton. Bones that are affected by Paget's disease are darker than normal on the scan.


In most cases, Paget's disease progresses slowly. The disease can be managed effectively in nearly all people, and is rarely fatal.

Osteoarthritis is one of the most common long-term complications of Paget's disease. Rarely, if the disease affects bones in your head, you may experience hearing loss, vision loss and loss of teeth.

Unusually extensive Paget's disease may force your heart to work harder to pump blood to the affected areas of your body. In people with pre-existing heart disease, this increased workload can lead to heart failure.

Another rare complication is a bone cancer known as sarcoma, also called osteosarcoma or osteogenic sarcoma, which may develop in bones affected by Paget's disease. This complication occurs in less than 1 percent of people with Paget's disease and usually doesn't develop until many years after the onset of Paget's.

Paget's disease of bone > 1 > 2 > 3 > 4

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