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Respiratory System


Chronic obstructive pulmonary disease (COPD) is a general term for a group of diseases that cause progressive damage to your lungs.

These diseases include:

  • chronic bronchitis,
  • chronic obstructive bronchitis
  • emphysema.

Emphysema develops gradually, and you may not experience symptoms until long-term damage to the tiny air sacs in your lungs (alveoli) causes you to feel short of breath. In fact, shortness of breath is usually the first symptom of the disease.

Cigarette smoking is the major cause of emphysema, accounting for more than 80 percent of all cases. Emphysema occurs most often in people older than age 40 who have smoked for many years. Long-term exposure to secondhand smoke also may play a role.

In addition to affecting your breathing, emphysema increases your risk of pneumonia, asthma, acute and chronic bronchitis, and other serious respiratory diseases. It's not uncommon for smokers to have emphysema, chronic bronchitis and asthma at the same time. Smokers with COPD also have an increased risk of lung cancer.

Signs and symptoms

Emphysema may produce the following signs and symptoms:

  • Shortness of breath (dyspnea). As emphysema progresses, you're likely to become increasingly short of breath. In time, you may have trouble breathing even when you're lying down. Breathing may be especially difficult during and after respiratory infections, such as colds or the flu.

  • Chronic, mild cough. You may produce sputum or phlegm when you cough.

  • Loss of appetite and weight loss. It's a vicious cycle. Emphysema can make eating more difficult, and the act of eating can rob you of your breath. The result is that you simply may not feel like eating much of the time.

  • Fatigue. Because it's more difficult to breathe and your body's getting less oxygen, you feel tired.


When you inhale, air travels to your lungs through two major airways called bronchi. Inside your lungs, the bronchi subdivide nearly 20 times into a million smaller airways (bronchioles), which finally end in clusters of tiny air sacs. You have about 300 million air sacs in each lung. Within the walls of the air sacs are small blood vessels (capillaries) where oxygen is added to your blood and carbon dioxide — a waste product of metabolism — is removed.

The air sac walls also contain elastic fibers that help them expand and contract like small balloons when you breathe. But in emphysema, inflammation destroys these fragile walls, causing them to lose their elasticity. As a result, the bronchioles collapse when you exhale, and air becomes trapped in the air sacs, which overstretches them.

In time, this overstretching (hyperinflation) may cause several air sacs to rupture, forming one larger air space instead of many small ones. Because the larger air sacs aren't able to force air completely out of your lungs when you exhale, you have to breathe harder just to get enough oxygen and eliminate carbon dioxide.

What causes emphysema?
Most damage to the elastic fibers and other supporting structures in your air sacs and small airways results from inflammation caused by tobacco smoke and other air-borne irritants. The process begins when tobacco smoke temporarily paralyzes the microscopic hairs (cilia) that line your bronchial tubes. Normally, these hairs sweep irritants and germs out of your airways. But when smoke interferes with this sweeping movement, irritants remain in your bronchial tubes, inflaming the tissues and eventually breaking down the elastic fibers.

A small number of people are born with a deficiency of a protein called alpha-1-antitrypsin (AAT), which normally protects the elastic fibers in the walls of your air sacs. People who have too little AAT are likely to develop severe emphysema in their 30s or 40s — a condition called AAT deficiency-related emphysema.

Risk factors

The single greatest risk factor for emphysema is smoking, which accounts for at least 80 percent of all cases of the disease. Emphysema is most likely to develop in cigarette smokers, but cigar and pipe smokers also are at risk. Men are affected more often than women, but this statistic is changing as more women begin to smoke.

Other risk factors include:

  • Exposure to secondhand smoke. Secondhand (passive) smoke is smoke you inadvertently inhale from someone else's cigarette, pipe or cigar. Breathing this smoke increases your risk of emphysema and other respiratory diseases.

  • Occupational exposure to chemical fumes. If you breathe fumes from certain chemicals at work or dust from grain, cotton, wood or mining products, you're more likely to develop emphysema. The risk is even greater if you smoke.

  • Exposure to indoor and outdoor pollution. If you smoke, breathing certain indoor pollutants — such as fumes from home heating fuels — as well as outdoor pollutants, increases your risk of emphysema.

  • Heredity. A rare inherited deficiency of the protein alpha-1-antitrypsin (AAT), which protects your lungs from a destructive enzyme, also can cause emphysema, especially before age 50, and even earlier if you smoke. A blood test can detect the deficiency.

Emphysema > next > 1 > 2 > 3 > 4 >

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This information is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient's medical condition.

In no event will the be liable for any decision made or action taken in reliance upon the information provided through this web site.
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