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Hodgkin's disease - Hodgkin's lymphoma
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Hodgkin's disease - Hodgkin's lymphoma

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CANCER

Lymphoma

 

Treatment

The most important factor in the treatment of Hodgkin's disease is the stage of the disease, which is usually determined by a CT scan or a PET scan. The number and regions of lymph nodes affected and whether only one or both sides of your diaphragm are involved are also important considerations. Other factors affecting decisions about treating this disease include:

  • Age

  • Symptoms

  • Whether you're pregnant

  • Overall health status

The goal of treatment is to destroy as many malignant cells as possible and bring the disease into remission. More than 80 percent of people with stage I or stage II Hodgkin's disease survives for 10 years or more with proper treatment. The five-year survival rate for those with widespread Hodgkin's disease is about 60 percent.

Treatment options include:

  • Radiation. When the disease is confined to a limited area, radiation therapy is the treatment of choice. It's typical to radiate the affected nodes and the next area of nodes where the disease might progress. The length of radiation treatment varies depending on the stage of the disease. Radiation therapy may be used alone, but is commonly used in conjunction with chemotherapy. If you relapse after radiation therapy, chemotherapy becomes necessary. Some forms of radiation therapy may increase the risk of other forms of cancer, such as breast or lung cancer. The risk of breast cancer from standard dose radiation is even higher for teenage girls than for other people and is generally too high for this therapy to be considered. Most children with Hodgkin's disease are treated with combination chemotherapy, but may also receive low-dose radiation therapy.

  • Chemotherapy. When the disease progresses and involves more lymph nodes or other organs, chemotherapy is the preferred treatment. Chemotherapy uses specific drugs in combination to kill tumor cells. A major concern with chemotherapy is the possibility of long-term side effects and complications, such as heart damage, kidney damage, liver damage and secondary cancers such as leukemia. Although these severe effects occur in only a small number of patients, great effort is being put into finding equally effective regimens with less toxicity. Drug regimens have been developed that substantially diminish the likelihood of long-range, life-threatening complications, including acute leukemia in people who have received multiple courses of chemotherapy and radiation therapy. These regimens are commonly referred to by their initials, such as ABVD (Adriamycin (doxorubicin), bleomycin, vinblastine, dacarbazine), BEACOPP (bleomycin, etoposide, Adriamycin, cyclophosphamide, Oncovin, procarbazine, prednisone), COPP/ABVD (cyclophosphamide, Oncovin, procarbazine, prednisone, Adriamycin, bleomycin, vinblastine, dacarbazine), Stanford V (Adriamycin, vinblastine, mechlorethamine, etoposide, vincristine, bleomycin, prednisone) and MOPP (mechlorethamine, Oncovin, procarbazine, prednisone). MOPP had been the basic regimen, but it's very toxic. ABVD is a newer regimen, with less severe side effects, and is currently the preferred treatment. BEACOPP may be more effective than the COPP/ABVD combination at treating recurrent Hodgkin's disease, though it may also have significant side effects.

  • Bone marrow transplant. If the disease recurs after an initial chemotherapy-induced remission, high-dose chemotherapy and transplantation of your own (autologous) bone marrow or peripheral stem cells may lead to prolonged remission. Peripheral stem cells are bone marrow cells mobilized from the bone marrow into the bloodstream. Because high doses of chemotherapy destroy bone marrow, your own marrow or peripheral blood stem cells are collected before treatment and frozen. You'll undergo chemotherapy, and then your own cells, which have been protected from the effects of the treatment, are injected back into your body.

Hodgkin's disease - Hodgkin's lymphoma > 1 > 2 > 3 > 4

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Disclaimer

This information is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient's medical condition.
In no event will The DrEddyClinic.com be liable for any decision made or action taken in reliance upon the information provided through this web site.

 


 



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Last Modified : 03/14/08 11:35 PM