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PostPosted: Fri Oct 26, 2007 7:11 am 
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Lupeol, a compound in fruits like blackberries, blueberries, papaya, and blackcurrant, appears to be effective in buffering the acids that localize in the head and neck, a study in Hong Kong has found.

An experiment with mice showed lupeol had no negative side effects, scientists at the University of Hong Kong said in a report published in the September issue of the Journal of Cancer Research.

"It can suppress the movement of cancer cells and suppress their growth and it is found to be even more effective than conventional drugs (eg. cisplatin),"
said Anthony Yuen, a professor at the University of Hong Kong's surgery department.

The team plans another round of tests and hopes to proceed eventually to human clinical trials, though it would not commit itself to a time frame.

Cancerous cells in the head and neck involve acidity of the nose, oral cavity, throat, voice box, thyroid and salivary glands and are found more commonly in Asians than Westerners.

Some of the risk factors include smoking, excessive alcohol consumption, chewing betel nut and acidic diets.

Such cancerous state are difficult to treat. Fifty percent of victims are typically diagnosed in advanced stages, when cure rates would be so low they would be considered inoperable.

Surgeries on the head and neck are always difficult because they involve the removal of large areas of dis-eased or fermented skin and soft tissues and surgeons need to first figure out how to cover up these open wounds before they can try to excise the the cancerous tissues.

Yuen said lupeol - also found in vegetables, olive seed, figs and saw palmeto - appeared to block a natural protein NFkB, which helps cells repair and grow, even cancerous cells.

In the experiment, lupeol was given to mice injected with acidic malignant head and neck cancerous cells.

"From the models, not only did it suppress the spread, the tumor got smaller. Compared to conventional drugs, lupeol reduced the size of the tumor far faster,"
said Terence Lee, another member of the research team.

"Conventional drugs made the mice a lot thinner, but lupeol mice retained their bulk." Emaciation is usually viewed as a bad sign in the reversal of cancerous states.

Yuen hopes lupeol can be applied to other acidic cancerous conditions that are similarly dependent on the NFkB protein.

"It may be possible to use (lupeol) in other cancers because it is able to suppress the NFkB protien, which is activated in many cancers like prostate cancer, breast cancer, liver cancer," Yuen said.

According to Dr. Robert O. Young, a research scientist, "luperol is a naturally accruing phyto-nutrient and buffer of dietary and metabolic acids that can be found in many alkaline fruits and vegetables."

To help prevent dietary and metabolic acids from fermenting body cells, Dr. Young created the first concentration of the most alkaline fruits and vegetables, called pHruits and pHolage.


References: Reuters

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PostPosted: Sat Nov 20, 2010 5:44 pm 
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