ScienceDaily
August 9, 2006

Antioxidants May Protect Against Tick-borne Illness Science Daily For hikers, campers and others who enjoy the outdoors, summer can bring concerns about tick bites and related illnesses such as Rocky Mountain spotted fever. Researchers are investigating the role that antioxidants -- alpha-lipoic acid and potentially others like green tea and vitamins C and E, for example -- might play in preventing or treating the deadly rickettsia bacteria.

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The National Institute of Allergy and Infectious Disease, part of the National Institutes of Health, awarded the University of Rochester Medical Center $2 million for a five-year study of the antioxidant theory. The grant caps more than a decade of ric! kettsia research led by Sanjeev Sahni, Ph.D.

Rocky Mountain spotted fever is the most frequently reported illness in the United States caused by the rickettsia bacteria, which is transmitted by tick parasites. It usually afflicts otherwise healthy adults and children who are bitten by wood ticks or dog ticks. The illness can become life threatening if left untreated, and spotted fever can be difficult for physicians to diagnose because the earliest signs mimic less-serious viral illnesses. Limiting exposure to ticks is the best way to prevent the disease. If it does develop, in most cases doctors can treat it with antibiotics. Typhus is another rickettsial disease spread by lice or fleas.

Although less common, typhus remains a threat in crowded jails and in other poor hygienic environments.

"Our studies have the potential to identify novel therapeutic targets for a host of rickettsial diseases," said Sahni, an assistant professor in Hematology/Oncology at the University of Rochester.

Dr. Howard Taylor Ricketts, who eventually died of typhus, identified rickettsia in the late 1800s. Sahni's research group first began investigating the rickettsia bacteria as a model to study the biological changes that occur in the lining of the blood vessels (endothelium) as the bacteria travels through the blood stream. Initially they were looking at what types of cellular changes occur in response to the infection. They discovered that cells undergo oxidative stress and produce harmful free radicals, causing inflammation and other complications.

Researchers hypothesized that antioxidants might serve as useful therapies after examining the damage to infected cells, as seen by electron microscopy, and through biochemical evidence proving oxidative stress (OS), a term used to describe a level of damage in cells, tissue and organs. Antioxidants can generally neutralize free radicals and reduce oxidative damage. Earlier experiments in which scientists infected cells with rickettsia bacteria and then treated the cells with alpha-lipoic acid, a powerful antioxidant, showed that the infected cells did, indeed, marshal a defense against the bacteria.

Sahni is also investigating what enzymes might boost antioxidants to work more efficiently. His group is studying the process that occurs when infected cells express cyclooxygenase (Cox-2) and prostaglandins, which results in inflammation. This biological process is what causes the severe swelling in the limb that was bitten by a tick harboring the rickettsia bacteria. Sahni theorizes that regulating the Cox-2 response with Cox-2 inhibitors such as ibuprofen could also help control the disease.
The University of Rochester team is collaborating with David J. Silverman, Ph.D., of the University of Maryland.

Note: This story has been adapted from a news release issued by University of Rochester Medical Center.

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Late Breaking News! โ€ขNew speaker added - Guissepina Feingold, M.D.

L.I.A Foundation Presents..... The Lyme-Autism Connection Conference and Physician's Training
When: June 22nd - 24th , 2007
Where: Hyatt Regency Hotel - Irvine, California
Hours: Friday - Special pre-conference workshop 7:00 p.m. - 10:00 p.m. Homeopathy Center of Houston
Saturday - General Session 8:00 a.m. - 5:40 p.m.
Sunday - General Session and Physician's Training (2-tracks) 8:00 a.m. - 5:00 p.m.
Where: Hyatt Regency Hotel in Irvine, California Just 5 minutes from the Orange County Airport
Register after May 30th - $175

Physicians, parents and patients from across the country are invited to learn about Lyme disease and it's impact on our children. Hundreds, if not thousands of children have been diagnosed with Lyme Disease and Autism. It's time to bring the experts from each of these areas together to find answers for our kids. Please join us and learn about proper testing, diagnosis, the unique needs of an autistic child and participate in the physicians training to search for the best treatments. This conference is appropriate for parents of children diagnosed with autism, Lyme Disease , add/adhd, asperger's syndrome or adults with Lyme disease. Here's a sampling of some of our speakers...

Charles Ray Jones, M.D. General Session: Keynote SpeakerPhysicians' Training: "The Proper Testing, Diagnosis and Treatment for Children with Lyme Disease" and Q & A.Dr. Jones is considered the leading pediatric Lyme specialist in the country. He has treated thousands of children with Lyme disease and countless who have exhibited autistic symptoms.Robert Bransfield, M.D., D.F.A.P.A.General Session: "The Association Between Lyme Disease and Autism"Physicians' Training: "Psychopharmacological Treatments for Autism"A private practice in Red Bank, NJ with an emphasis upon treatment resistant cases; Vice President of American Psychiatric Association Managed Care Committee; Author of numerous publications on the psychological impact of Lyme Disease.

W.Lee Cowden, M.D.General Session: "Laser Energetic Detoxification to Rapidly Improve Autism"Physicians' Training: "Non-Pharmaceutical Treatment of Lyme Disease as a Key in Reversing Autism"William Lee Cowden, M.D. is a board certified Cardiologist and Specialist in Internal Medicine. Internationally known and recognized for his proficient technique in the use of Evaluative Kinesiology, Dr. Cowden has refined treatment protocols for Cancer, Lyme Disease, Autism, Parkinson's Disease, Fibromyalgia, Chronic Fatigue, as well as many other medical conditions including reversing Heart and Vascular Disease.Anju Usman, M.D.General Session: "Nutritional and Biomedical Approach to Patients with Chronic Infections"Dr. Usman is a DAN! practitioner (Defeat Autism Now!) who is one of the most respected in her field.Professor Garth Nicholson

General Session: "Chronic Co-Infections in Autism Spectrum Disorders"Professor Nicholson is the founder of the Institute of Molecular Medicine and has been researching Gulf War Syndrome, Mycoplasma and it's impact on autistic children.Geoffrey Radoff, M.D., M.D.(h)

General Session: "A Comprehensive Approach to Lyme Disease and Autism Using Allopathic, Homeopathic and Integrative Medicine"Dr. Radoff is al respected DAN! practitioner and homeopathic M.D. who uses diverse methodologies in the treatment of Lyme disease and autism.Jeff Wulfman, M.D.General Session: "Lyme Disease, Chronic Borreliosis and Borrelia Related Complex - A Framework for Understanding Complex Illness"Physicians' Training: "Herbal and Nutraceutical Options in Chronic Infections Including Borrelia."Dr. Wulfman is a practicing Integrative Family Physician from Vermont and is an Assistant Clinical Professor of Family Medicine through the University of Vermont.

He has a full-spectrum Family Practice that includes pursuing a comprehensive approach to chronic complex illnessesincluding chronic infections and autism spectrum disorders. He has lectured in the US and Canada on these topics as well as on the mind-body-spirit connections in health and illness. He also has developed and led multi-day retreats for patients with Lyme Disease and other chronic illness.Lisa AckermanGeneral Session: "Who pays for what?... will help parents understand the different funding options available for traditional and biomedical therapies"

Lisa is the founder and Executive Director of TACA - Talk about Curing Autism and Jeff's mom. Kristen MartinezGeneral Session: "A Story of Recovery, What is a Herxheimer Reaction?"Kristen is the mother of a little boy who has lost his autism diagnosis and fully recovered by treating his borrelia (Lyme) infection.

John Kucera, M.D.General Session: "Heavy Metal etoxification"Physicians' Session:

Moderator Dr. Kucera is a DAN! practitioner who specializes in the treatment of autistic children. He is extremely knowledgeable on all aspects of treatment for autism especially detoxification and heavy metal protocols.Sue Massie, CNHPGeneral Session: "Children, Our Greatest Investment, How Do We Protect Them?"

As a Certified Natural Health Provider and Naturopathic Doctor candidate, Sue educates clients worldwide about degenerative, neurological disease along with nutritional counseling.Anthony R. Torres, M.D.General Session: "Immune Genes Associations in Autism"Dr. Torres is the laboratory director for the Center for Persons with Disabilities at Utah State University, in Logan, Utah. He is also the head of the L.I.A. Foundation Scientific Advisory Board. Mady Hornig, M.A., M.D.General Session: "Immunity and Redox Redux: Infectious and Immunotoxic Factors in Autism and Other Neurodevelopmental Disorders"Greene Infectious Disease Laboratory, Mailman School of Public Health, Columbia UniversityAristo Vojdani, Ph.D., M.T.General Session: "Immunology of Lyme Disease and Associated Disorders"

Dr. Vojdani is the Chief Executive Officer of Immunosciences Lab in Beverly Hills, CA.Doris Rapp, M.D.General Session: "Pollutants and Poisons - Tips to Keep You Well"Board Certified Environmental Medical Specialist, Pediatric AllergistDr. Rapp has been a featured guest on Larry King Live, Oprah, Montel Williams, Maury Povich and more.Homeopathy Center of HoustonCindy Griffin and Lindyl Lannham from Houston will be sharing their unique homeopathic approach to treating Lyme disease and autism. There information will be shared at the special Friday night pre-conference workshop. Guiseppina Feingold, M.D.General Session: "Higher Pressure Oxygen Therapy for the Treatment of Lyme disease and Autism."Dr. Feingold is one of the leading DAN! Practitioners on the forefront of treatment techniques for children with Lyme disease and autism spectrum disorder. Speakers subject to change

Online Registration: http://www.lymeinducedautism.com/seminarregistration.html Exhibitor Information: http://www.lymeinducedautism.com/seminarregistration/exhibitorregistration.html