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Complex regional pain syndrome (CRPS)
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Complex regional pain syndrome (CRPS)

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Complex regional pain syndrome (CRPS) is an uncommon, chronic condition that usually affects your arm or leg. Very rarely, the disease can affect other parts of your body. You may experience intense burning or aching pain along with swelling, skin discoloration, altered temperature, abnormal sweating and hypersensitivity in the affected area.

The nature of CRPS is puzzling, and the cause isn't clearly understood. The condition may result from disturbances in the sympathetic nervous system, the part of the nervous system that controls blood flow and your sweat glands. The disease commonly follows an acute problem. Most often, CRPS is preceded by a major injury to an arm or a leg, but it may also be triggered by an illness such as a heart attack or a minor injury you can't even recall.

Screening and diagnosis

Your doctor may base a diagnosis of CRPS on:

  • Review of your medical history. The onset of CRPS symptoms can be traced back to an accident, illness or injury in the majority of cases.

  • Physical examination. An examination of your skin, muscles and joints may reveal information about the source of your tenderness and pain. There may be changes in the normal texture and color of your skin, and you may have problems with range of motion of one or more of your joints.

  • Bone scan. A radioactive substance injected into your veins permits viewing of your bones with a special camera. This procedure may show a loss of calcium from your bones (osteoporosis) or increased circulation to the joints in the affected area.

  • Thermography. Tests that measure skin temperature and blood flow may show a difference between your affected and unaffected limbs.

  • X-rays. Loss of minerals from your bones may show up on an X-ray in later stages of the disease.

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This information is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient's medical condition.
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Last Modified : 03/15/08 02:00 AM