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Paget's disease of bone
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Paget's disease of bone

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From MayoClinic.com 


It's related to a viral infection in your bone cells that may be present for many years before symptoms appear. Hereditary factors appear to influence whether you're susceptible to the disease.

Risk factors

Age and heredity are the only known risk factors for Paget's disease. Occasionally, the disease runs in families.

People older than age 40 are the most likely to develop Paget's disease.

When to seek medical advice

Detecting Paget's disease early may help prevent serious complications. If you have a sibling or parent with Paget's disease, ask your physician about having an alkaline phosphatase blood test every couple of years after age 40. Alkaline phosphatase is produced by bone cells that are responsible for forming new bone and is elevated in most people with Paget's disease.

Talk to your doctor if you have:

  • Symptoms of Paget's disease, such as pain in your bones and joints

  • Symptoms of pinched nerves, such as pain, tingling and weakness

  • Bone deformities

If you have Paget's disease, contact your physician if you experience:

  • Signs and symptoms of the disease affecting your skull, such as hearing or vision loss, double vision, facial weakness or numbness

  • Loss of bladder or bowel control accompanied by weakness in your legs, which can indicate severe spinal damage

  • Sudden or severe pain or a change in the pain that you've been experiencing


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Last Modified : 03/15/08 01:42 AM