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Multiple myeloma
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Multiple myeloma

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CANCER

Lymphoma

From MayoClinic.com

 

When to seek medical advice 

If you're persistently more tired than you used to be, you've lost weight, and you experience bone pain, repeated infections, loss of appetite, excessive thirst and urination, persistent nausea, increased constipation, or weakness or numbness in your legs, these may indicate multiple myeloma or other serious diseases. See your doctor to determine the underlying cause.

Screening and diagnosis

Your doctor may first detect signs of multiple myeloma before you ever have symptoms — through blood and urine tests conducted during a routine physical exam.

Generally, doctors conduct a blood test called serum protein electrophoresis as part of an exam. This test separates your blood proteins and can detect the presence of abnormal, M proteins in the blood. Parts of M proteins may also be detected in a test of your urine — referred to as Bence Jones proteins.

If your doctor discovers M proteins, you'll likely need additional blood tests to measure blood cell counts and levels of calcium, uric acid and creatinine. Your doctor may also conduct other blood tests to check for beta-2-microglobulin — another protein produced by myeloma cells — or to measure the percentage of plasma cells in your blood.

You may also need other tests. X-rays of your skeleton can show whether your bones have any thinned-out areas, common in multiple myeloma. If a closer view of your bones is necessary, your doctor may use magnetic resonance imaging (MRI) or computerized tomography (CT) scanning. Your doctor may also conduct a bone marrow examination by using a needle to remove a small sample of bone marrow tissue. The sample is then examined under a microscope to check for myeloma cells.

These tests can help confirm whether you have multiple myeloma or another condition. If tests indicate you have multiple myeloma, the results from these tests allow your doctor to classify the stage of myeloma. Stages range from Stage I (low amount of myeloma) to Stage III (high amount of myeloma) and A (normal kidney function) or B (abnormal kidney function) — as multiple myeloma often causes damage to your kidneys.

 

Multiple myeloma > 1 > 2 > 3 > 4

 

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