- enlarged hands
- enlarged feet
- widened fingers or toes due to skin overgrowth with swelling,
redness, and pain
- enlarged jaw (prognathism) and tongue
- enlarged facial bones
- thickening of the skin, skin tags
- enlarged sebaceous glands
muscle strength (weakness)
- limited joint mobility
- joint pain (hip pain, knee pain, ankle pain, foot pain, pain
over the small joints of the foot, shoulder pain, elbow pain, wrist
pain, hand pain, pain over the small joints of the hand, or pain in
any other joint)
Carpal tunnel syndrome
- widely spaced teeth
- swelling of the bony areas around a joint
Additional symptoms that may be associated with this disease:
- weight gain (unintentional)
- hair, excessive on females
- The level of
growth hormone is high.
- The level of IGF-1 (insulin-like growth factor 1) is high.
spine X-ray shows abnormal bone growth.
cranial MRI or
cranial CT scan may show a
The pituitary, a small gland located at the base of your brain behind
the bridge of your nose, produces a number of hormones. One hormone,
called growth hormone (GH), plays an important role in managing your
physical growth. When GH is secreted into your bloodstream, it triggers
your liver to produce a hormone called insulin-like growth factor-I (IGF-I).
In turn, IGF-I stimulates the growth of bones and other tissues. If your
pituitary gland makes too much GH, excessive amounts of IGF-I can
result. Too much IGF-I can cause abnormal growth of the skeleton and
other signs and symptoms characteristic of acromegaly and gigantism.
In adults, a tumor is the most common cause of too much GH production:
In 99 percent of people with acromegaly, the cause is a noncancerous
(benign) tumor (adenoma) of the pituitary gland. The tumor secretes
excessive amounts of growth hormone causing many of the signs and
symptoms of acromegaly. Some of the symptoms of acromegaly, such as
headaches and impaired peripheral vision, are due to the tumor mass
pressing on nearby brain tissues.
In a small percentage of people with acromegaly, tumors in other
parts of the body, such as the lungs, pancreas, ovaries or adrenal
glands, cause the disorder. Sometimes, these tumors actually secrete
GH. In other cases, the tumors produce a hormone called growth
hormone-releasing hormone (GH-RH), which stimulates the pituitary to
make more GH.
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