Sanskrit Name: Meshasringi
Latin: Gymnema sylvestre R.Br.
Vernacular names: Sanskrit - Meshasringa; Hindi - Gurmar; English - Gurmar; Unani - Gokhru; Tamil - Sirukurinjan
Part Used: root, leaves
Traditional Ayurvedic Uses: possible sugar-reducing properties in diabetes (type 2), snakebite, excellent for everyone to purify the blood
Leaves were found to contain active principles which cause inhibition of the hyperglycemic respond in rats. Research to date in encouraging but incomplete.
Doshas: Kapha-, Vata-, Pitta+
Pharmacological Action: diuretic, astringent, hypoglycemic, refrigerant, stomachic
Clinical Research: The leaf powder caused a clinically insignificant decrease in serum glucose in normal rats but a significant reduction in serum glucose in experimentally induced hyperglycemic animals. Body weight and urine output both increased in rats treated with the herb. Both of these effects may be due to stimulation of pancreatic insulin secretion. There is however currently no good evidence to show that G. sylvestre powder or extract has any effect on the serum or urine glucose concentrations of humans suffering from diabetes mellitus. no water-soluble or alcohol-soluble constituents which have glucose-destroying action in vitro have been isolated.
Traditional Uses: Diabetes mellitus, snakebites (root powder), fever, and cough. In Ayurveda, G. sylvestre also is used to treat somatic burning sensations, biliousness, hemorrhoids, and urinary disorders. When chewed the leaves have the remarkable property of abolishing the ability to taste sweet and bitter substances. It also has a mild laxative effect, probably due to its anthraquinone content which irritates the bowel walls (similar to Cassia angustifolia, rhubarb, or the aloes.)
Indications: type 2 diabetes mellitus as an adjunct to other treatments, snakebite.
Gupta SS, Seth,
CB, Experimental studies on pituitary diabetes, Ind J Med Res., 50, 708,